This site is intended for healthcare professionals only.

This site is intended for healthcare professionals only.

Decoding HER2 mutations and overexpression in NSCLC

Patients with advanced non-small cell lung cancer (NSCLC) driven by HER2 mutations or HER2 overexpression continue to experience aggressive disease behavior and poor outcomes. Key challenges persist, including accurately identifying HER2 aberrations, navigating treatment efficacy and toxicity, and managing the high incidence of brain metastases.

As novel HER2-targeted therapies—such as antibody-drug conjugates (ADCs), tyrosine kinase inhibitors (TKIs), and emerging combination strategies—offer more targeted treatment options, timely integration of these options into clinical practice is essential to improve patient survival and quality of life.

This program will strengthen your competency in HER2 biomarker testing to ensure accurate detection and patient selection for targeted treatments, while providing practical guidance to increase your confidence in implementing HER2-targeted therapies in NSCLC, including educational resources to expand your knowledge of their efficacy and safety in patients with brain metastases.

Whats next?

Add Your Heading Text Here

HER2-targeted therapies in practice

With David Planchard

Video-based case study to explore current HER2-targeted approaches in NSCLC and the application of data to patient selection and treatment.

Add Your Heading Text Here

Managing brain metastases in HER2-positive NSCLC

With Enriqueta Felip

Video-based case study exploring the management of brain metastases in HER2-positive NSCLC, using clinical data from HER2-targeted therapies.

Add Your Heading Text Here

HER2 biomarker testing in practice

Enriqueta Felip joined by Fernando López-Ríos

With a focus on detecting HER2 mutations and overexpression in NSCLC, the first podcast in this series will provide practical guidance in the context of real-world barriers.

Add Your Heading Text Here

Practical considerations for implementation of HER2-targeted therapies

Enriqueta Felip joined by David Planchard

The second episode in the podcast series will cover practical considerations for implementing HER2-targeted therapies in NSCLC care, including the management of toxicities and integration of multidisciplinary workflows.

Add Your Heading Text Here

Future directions in HER2-positive NSCLC

Enriqueta Felip joined by…

The final episode in this podcast series will look to the future, with expert perspectives on what is to come for treatment and management of HER2-positive NSCLC.

Add Your Heading Text Here

HER2 biomarker testing in NSCLC

Cheat sheet

Tips on how to incorporate HER2 biomarker testing in NSCLC into workflows in clinical practice.

Add Your Heading Text Here

Managing adverse events with HER2-targeted therapies in NSCLC

Clinican aid

A concise clinical reference guide addressing key adverse events associated with HER2-targeted treatments.

Case
navigator

Apply evidence directly to patient care.

Experts in
conversation

Overcome challenges to implement knowledge into practice.

Clinical
aid

Action tools to guide at the point-of-care.

Learning objectives

Following completion of this independent educational program, you will be able to:

Target audience

This program is intended for oncologists, pathologists, pulmonologists and oncology nurses, physician assistants, and those in the multidisciplinary teams worldwide who provide front-line care for patients with NSCLC.

Meet the experts

Enriqueta Felip

Program Director – Section Chief (HUVH) and Head of Thoracic Tumors Group (VHIO)

Vall d’Hebron University Hospital (HUVH), Vall d’Hebron Institute of Oncology (VHIO), Barcelona Spain

David Planchard

Medical Thoracic Oncologist

Institut Gustave Roussy (IGR) (Medical Department of Oncology), Villejuif and Paris-Saclay University, Paris, France

Fernando Lopez-Rios

Fernando Lopez-Rios

Director, Molecular Diagnostics Service

Hospital Universitario 12 de Octubre, Madrid, Spain

Human epidermal growth factor receptor 2 (HER2) is a transmembrane receptor tyrosine kinase encoded by the ERBB2 gene